Publications

2024

Benjamin Wittevrongel, Caroline Neuray, Alex Grant, Baharan Kamousi, Raymond Woo, Pieter van Mierlo

Assessing the Viability of Automated Sleep Scoring in an ICU Environment Using a Compact EEG Configuration

Artificial Intelligence in Epilepsy and Neurological Disorders 2024 conference abstract

2023

Jason Lerner, Bharat Awsare, Heather Sevinsky, Eric Ashbrenner, Randall Killingsworth, Rachael Kendrick, Emiel Vereycken, Nigel Colenbier, Caroline Neuray, Pieter van Mierlo, Jeremy Slater, David Wyatt, Irfan Qureshi, Steven Dworetzky, Michael Bozik

Novel, Selective Kv7.2/7.3 Potassium Channel Activator, BHV-7000, Demonstrates Dose-Dependent Pharmacodynamic Effects on EEG Parameters in Healthy Adults

AES 2023 conference abstract

2023

Caroline Neuray, Brecht Nerinckx, Ekatherina Garzon, Pieter van Mierlo, M. Scott Perry, Kelly G Knupp, Joseph Sullivan, Susana Boronat, Matt Lallas, Andreas Brunklaus, Salvador Rico, Jacqueline S Gofshteyn

Decoding Dravet Syndrome: The Role of Advanced EEG Analytics in Phenotyping

AES 2023 conference abstract

2023

Laurent Spinelli , Amir G. Baroumand, Serge Vulliemoz, Shahan Momjian, Gregor Strobbe, Pieter van Mierlo, Margitta Seeck

Semi‐automatic interictal electric source localization based on LTM EEG: a prospective study

IEC 2023 conference abstract

2023

Amir G. Baroumand, Roberto Santalucia, Riëm El Tahry, Pieter van Mierlo

Interictal and ictal EEG source imaging in children below 6 years of age with curative epilepsy surgery: a retrospective, blinded clinical study

IEC 2023 conference abstract

2023

Gadi Miron, Thomas Baag, Kara Götz, Martin Holtkamp, Bernd J. Vorderwülbecke

Integration of interictal EEG source localization in presurgical epilepsy evaluation – A single-center prospective study

Epilepsia Open

2023

Roberto Santalucia, Evelina Carapancea, Simone Vespa, Enrique Germany Morrison, Amir Ghasemi Baroumand, Pascal Vrielynck, Alexane Fierain, Vincent Joris, Christian Raftopoulos, Thierry Duprez, Susana Ferrao Santos, Pieter van Mierlo, Riëm El Tahry

Clinical added value of interictal automated electrical source imaging in the presurgical evaluation of MRI-negative epilepsy: A real-life experience in 29 consecutive patients

Epilepsy & Behavior

2023

Laurent Spinelli, Amir G. Baroumand, Serge Vulliemoz, Shahan Momjian, Gregor Strobbe, Pieter Mierlo, Margitta Seeck

Semiautomatic interictal electric source localization based on long- term electroencephalographic monitoring: A prospective study

Epilepsia

2022

Kimberly A Parkerson, Pieter van Mierlo, Ekatherina Garzón Jirón, Eline Van Vlierberghe, Javier Avendaño, Linda Laux, Barry Ticho

Quantitative EEG Analysis in Patients with Dravet Syndrome (DS) Treated in the Phase 1/2a MONARCH and ADMIRAL Studies of STK-001, an Antisense Oligonucleotide (ASO)

AES 2022 conference abstract

2022

Amir G. Baroumand, Anca Arbune, Simone Vespa, Riëm El Tahry, Sandor Beniczky, Pieter van Mierlo

Evaluation of ictal EEG Source Imaging with sliding window approach to localize the epileptogenic focus: A bicentric retrospective study

AES 2022 conference abstract

2022

Jeffrey Buchhalter, Caroline Neuray, Jocelyn Y Cheng, O'Neill D'Cruz, Alexandre N Datta, Dennis Dlugos, Jacqueline French, Dietrich Haubenberger, Joseph Hulihan, Pavel Klein, Robert W Komorowski, Lynn Kramer, Amélie Lothe, Rima Nabbout, Emilio Perucca, Peter Van der Ark

EEG parameters as endpoints in epilepsy clinical trials – An expert panel opinion paper

Epilepsy Research

2022

Pia De Stefano, Eric Ménétré, Serge Vulliémoz, Pieter Van Mierlo, Margitta Seeck

Changes of interictal epileptiform discharges during medication withdrawal and seizures: A scalp EEG marker of epileptogenicity

Clinical Neurophysiology Practice

2022

Marcel Heers, Sebastian Böttcher, Adam Kalina, Stefan Katletz, Dirk-Matthias Altenmüller, Amir G. Baroumand, Gregor Strobbe, Pieter van Mierlo, Tim J. von Oertzen, Petr Marusic, Andreas Schulze-Bonhage, Sándor Beniczky, Matthias Dümpelmann

Detection of interictal epileptiform discharges in an extended scalp EEG array and high-density EEG – A prospective multicenter study

Epilepsia

2022

Markus Geschwind, Barbora Zima, Krassen Nedeltchev, Pieter van Mierlo, Stephan Rüegg

Tracking Multifocal Epilepsy With Automated Electric Source Imaging in a Patient With Triple-X Syndrome

Journal of Clinical Neurology

2021

Evelina Iachim, Simone Vespa, Amir G. Baroumand, Venethia Danthine, Pascal Vrielynck, Marianne de Tourtchaninoff, Alexane Fierain, Jose Geraldo Ribeiro Vaz, Christian Raftopoulos, Susana Ferrao Santos, Pieter van Mierlo, Riëm El Tahry

Automated electrical source imaging with scalp EEG to define the insular irritative zone: Comparison with simultaneous intracranial EEG

Clinical Neurophysiology

2021

Amir G. Baroumand, Bernd J. Vorderwülbecke, Laurent Spinelli, Margitta Seeck, Pieter van Mierlo, Serge Vulliémoz

Accuracy of automated interictal high density EEG source localisation

AES 2021 conference abstract

2021

Pieter van Mierlo, Amir Baroumand, Laurent Spinelli, Gregor Strobbe, Serge Vulliémoz, Margitta Seeck

Semi Automatic Electric Source Localization of Interictal Discharges During Entire Long Term Monitoring: A Prospective Study

AES 2021 conference abstract

2021

Detection of interictal epileptiform discharges in an extended scalp EEG array and high-density EEG

AES 2021 conference abstract

2021

Henrikas Vaitkevicius, Eva Rybak, Maxim Meersman, Pieter van Mierlo, Joseph Hulihan, Maciej Gasior

The Use of Quantitative EEG Spectral Analysis to Characterize IV Ganaxolone PK/PD Characteristics in Patients with Refractory Status Epilepticus

AES 2021 conference abstract

2021

Nadine Oser, Martina Hubacher, Annette Nageleisen-Weiss, Pieter van Mierlo, Reto Huber, Peter Weber, Bigna K. Bölsterli, Alexandre N. Datta

6-year course of sleep homeostasis in a case with epilepsy-aphasia spectrum disorder

Epilepsy & Behavior Reports

2021

Bernd J. Vonderwülbecke, Amir G. Baroumand, Laurent Spinelli, Margitta Seeck, Pieter van Mierlo, Serge Vulliémoz

Automated interictal source localisation based on high-density EEG

Seizure European Journal of Epilepsy

2021

Pieter van Mierlo, Gilles Van Loock, Pia De Stefano, Gregor Strobbe, Serge Vulliémoz, Margitta Seeck, Pål G Larsson

Electrophysiological effects in the first 48 hours after withdrawal of perampanel and levetiracetam in refractory epilepsy patients

2021

Amir G. Baroumand, Anca A. Arbune, Gregor Strobbe, Vincent Keereman, Lars H. Pinborg, Martin Fabricius, Guido Rubboli, Camilla Gøbel Madsen, Bo Jespersen, Jannick Brennum, Otto Mølby Henriksen, Pieter van Mierlo, Sándor Beniczky

Automated ictal EEG source imaging: A retrospective, blinded clinical validation study

Clinical Neurophysiology

2020

Pieter van Mierlo, Lena Habermehl, Vincent Keereman, Gregor Strobbe, Susanne Knake

Towards developing an EEG biomarker indicative of treatment efficacy of an antiseizure drug

2020

Amir G. Baroumand, Anca Arbune, Gregor Strobbe, Vincent Keereman, Pieter van Mierlo, Sándor Beniczky

Clinical validation study of automated ictal ESI

2020

Vénéthia Danthine, Riëm El Tahry, Simone Vespa, Evelina Iachim, Amir G. Baroumand, Gert Vanhollebeke, Gregor Strobbe, Geraldo Ribeiro Vaz, Pieter van Mierlo, Susana Ferrao Santos

Automated low-density Electrical Source Imaging to characterize insular irritative zone: an ESI-SEEG comparison

2020

E. Gleichgerrcht, J. Wilmskoetter, L. Phillips, A. Basilakos, C. Rorder, E. Kutluay, J.C. Edwards, J. Fridriksson, L. Bonilha

Award winning poster with MUSC for Epilog Brain Research Services in stroke

2020

Pieter van Mierlo, Lena Habermehl, Gregor Strobbe, Sally Rose, Pal Gunnar Larsson, Susanne Knake

Towards developing an antiseizure drug efficacy biomarker

2019

Margherita Carboni, Maria Rubega, Giannina Rita Iannotti, Pia De Stefano, Gianpaolo Toscano, Sébastien Tourbier, Francesca Pittau, P Hagmann, S Momjian, K Schaller, Margitta Seeck, CM Michel, Pieter Van Mierlo, Serge Vulliemoz

The network integration of epileptic activity in relation to surgical outcome

Clinical Neurophysiology

2019

Maria Rubega, Margherita Carboni, Martin Seeber, D Pascucci, S Tourbier, Giacomo Toscano, Pieter Van Mierlo, P Hagmann, G Plomp, Serge Vulliemoz, CM Michel

Estimating EEG source dipole orientation based on singular-value decomposition for connectivity analysis

Brain topography

2019

Maria Rubega, David Pascucci, J Rué Queralt, P Van Mierlo, P Hagmann, G Plomp, CM Michel

Time-varying effective EEG source connectivity: the optimization of model parameters*

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

2019

D Klooster, J Vink, P van Mierlo, P Boon, D Cooke, T Gedankien, A Roberts, P Boucher, A Pascual-Leone, M Fox, M Shafi

Propagation of TMS pulses versus functional brain connectivity

Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation

2019

Elissa-Marie Cocquyt, Patrick Santens, Pieter van Mierlo, Wouter Duyck, Arnaud Szmalec, Miet De Letter

Age-related differences in auditory semantic priming: the development of normative electrophysiological data in the Dutch population

Science of Aphasia

2019

Miet De Letter, Elissa-Marie Cocquyt, Nils Knockaert, Pieter van Mierlo, Arnaud Szmalec, Wouter Duyck, Patrick Santens

Phonologically related EEG as a more reliable diagnostic tool in the recovery of aphasia in the different stages after stroke.

Society for Neurobiology of Language

2019

Simone Vespa, Amir Ghasemi Baroumand, Susana Ferrao Santos, Pascal Vrielynck, Marianne de Tourtchaninoff, Gregor Strobbe, Odile Feys, Christian Raftopoulos, Pieter van Mierlo, Riëm El Tahry

Ictal EEG source imaging and connectivity to localize the seizure onset zone in extratemporal lobe epilepsy

33rd International Epilepsy Congress

2019

P Van Mierlo, Y Höller, NK Focke, S Vulliemoz

Network perspectives on epilepsy using EEG/MEG source connectivity

Frontiers in neurology

2019

Pieter van Mierlo, Pia De Stefano, Vincent Keereman, Gregor Strobbe, Margitta Seeck

Electrophysiological effects after withdrawal of Fycompa perampanel in the first 72h.

33rd International Epilepsy Congress Bangkok, Thailand 22 – 26 June 2019

2019

Jara Stalpaert, Elissa-Marie Cocquyt, Lieselot Segers, Tim Van Langenhove, Marijke Miatton, Pieter van Mierlo, Miet De Letter

Clinical and electrophysiological markers of Primary Progressive Aphasia: a systematic review

Research Day & Student Research Symposium

2019

Laurent Sheybani, Pieter van Mierlo, Gwénaël Birot, Christoph M Michel, Charles Quairiaux

Large-Scale 3–5 Hz Oscillation Constrains the Expression of Neocortical Fast Ripples in a Mouse Model of Mesial Temporal Lobe Epilepsy

Society for Neuroscience

2018

Ana Coito, Silke Biethahn, Janina Tepperberg, Margherita Carboni, Ulrich Roelcke , Margitta Seeck, Pieter van Mierlo, Markus Gschwind, Serge Vulliemoz

Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low‐density EEG

Epilepsia Open

2018

Markus Gschwind, Pieter van Mierlo, Stephan Rüegg

Little effort with big effect–implementing the new IFCN 2017 recommendations on standard EEGs

Epilepsia Open

2018

Baroumand, A. G., van Mierlo, P., Strobbe, G., Pinborg, L. H., Fabricius, M., Rubboli, G., ... & Henriksen, O. M.

Automated EEG source imaging: A retrospective, blinded clinical validation study

Clinical Neurophysiology

2018

van Mierlo P, Lie O, Staljanssens W, Coito A, Vulliémoz S

Influence of Time-Series Normalization, Number of Nodes, Connectivity and Graph Measure Selection on Seizure-Onset Zone Localization from Intracranial EEG

Brain Topography

2018

Thibault Verhoeven, Ana Coito, Gijs Plomp, Aljoscha Thomschewski, Francesca Pittau, Eugen Trinka, Roland Wiest, Karl Schaller, Christoph Michel, Margitta Seeck, Joni Dambre, Serge Vulliemoz, Pieter van Mierlo

Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes

Neuroimage Clinical

2017

Thibault Verhoeven, Ana Coito, Pieter van Mierlo, Margitta Seeck, Christoph Michel, Gijs Plomp, Joni Dambre, Serge Vulliemoz

Using Random Forest for Diagnosis and Lateralization of Temporal Lobe Epilepsy from EEG-based Directed Functional Connectivity

12th European Congress on Epileptology

2017

Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, Vincent Keereman, StefanieGadeyne, Evelien Carrette, Alfred Meurs, Francesca Pittau, Shahan Momjian, Margitta Seeck, Paul Boon, Stefaan Vandenberghe, Serge Vulliemoz, Kristl Vonck, Pieter van Mierlo

EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy

Neuroimage Clinical

2017

Pieter van Mierlo, Gregor Strobbe, Vincent Keereman, Gwénael Birot, Stefanie Gadeyne, Markus Gschwind, Evelien Carrette, Alfred Meurs, Dirk Van Roost, Kristl Vonck, Margitta Seeck, Serge Vulliémoz, Paul Boon

Automated long-term EEG analysis to localize the epileptogenic zone

Epilepsia Open

2017

Martinez-Vargas, J. D., Strobbe, G., Vonck, K., van Mierlo, P., & Castellanos-Dominguez, G.

Improved localization of seizure onset zones using spatiotemporal constraints and time-varying source connectivity

Frontiers in Neuroscience, 11.

2016

Strobbe, Gregor, Pieter van Mierlo, Vincent Keereman, … & Paul Boon.

“Epilog: a framework for automatic detection of epileptic spikes and subsequent EEG source imaging localizes the epileptogenic zone with high sensitivity and specificity.”

Abstracts European Congress Epilepsy 2016

2016

Montes-Restrepo, V., Carrette, E., Strobbe, G., Gadeyne, S., Vandenberghe, S., Boon, P., ... & van Mierlo, P. (2016).

The Role of Skull Modeling in EEG Source Imaging for Patients with Refractory Temporal Lobe Epilepsy.

Brain Topography, 1-18.

2016

Strobbe, Gregor, et al.

“Electrical source imaging of interictal spikes using multiple sparse volumetric priors for preoperative epileptogenic focus localization.”

NeuroImage: Clinical (2016).

2016

Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, Gwénaël Birot, Markus Gschwind, Margitta Seeck, Stefaan Vandenberghe, Serge Vulliémoz, Pieter van Mierlo

Seizure Onset Zone Localization from Ictal High-Density EEG in Refractory Focal Epilepsy

Brain Topography (2016): 1-15

2015

Vanhoutte, S., Santens, P., Cosyns, M., Van Mierlo, P., Batens, K., Corthals, P., ... & Van Borsel, J. (2015).

Increased motor preparation activity during fluent single word production in DS: A correlate for stuttering frequency and severity.

Neuropsychologia, 75, 1-10.

2015

Vanhoutte, Sarah, et al.

“Early lexico-semantic modulation of motor related areas during action and non-action verb processing.”

Journal of Neurolinguistics34 (2015): 65-82.

2014

Strobbe, Gregor, et al.

“Bayesian model selection of template forward models for EEG source reconstruction.”

NeuroImage 93 (2014): 11-22.

2014

Van Mierlo, Pieter, et al.

“Functional brain connectivity from EEG in epilepsy: Seizure prediction and epileptogenic focus localization.”

Progress in neurobiology 121 (2014): 19-35.

2014

Aerts, A., Strobbe, G., van Mierlo, P., Hartsuiker, R., Santens, P., & De Letter, M. (2016).

Spatiotemporal differentiation of neural activity in auditory and motor regions during pre-attentive and attentive phoneme discrimination.

Actua Neurologica Belgica

2014

Strobbe, Gregor, et al.

“Multiple sparse volumetric priors for distributed EEG source reconstruction.”

NeuroImage 100 (2014): 715-724.

2014

Montes-Restrepo, V., van Mierlo, P., Strobbe, G., Staelens, S., Vandenberghe, S., & Hallez, H. (2014).

Influence of skull modeling approaches on EEG source localization.

Brain topography, 27(1), 95-111. READ MORE

2013

Aerts, A., van Mierlo, P., Hartsuiker, R. J., Hallez, H., Santens, P., & De Letter, M. (2013).

Neurophysiological investigation of phonological input: Aging effects and development of normative data.

Brain and language, 125(3), 253-263.

2013

Strobbe, G., David, C. P., Montes Restrepo, V. E., van Mierlo, P., & Vandenberghe, S. (2013).

Selecting volume conductor models for EEG source localization of epileptic spikes: results based on 4 operated epileptic patients.

In International conference on basic and clinical multimodal imaging.

2013

Mierlo, P., Carrette, E., Hallez, H., Raedt, R., Meurs, A., Vandenberghe, S., ... & Vonck, K. (2013).

Ictal‐onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy.

Epilepsia, 54(8), 1409-1418.

2011

Van Mierlo, Pieter, et al.

“Accurate epileptogenic focus localization through time-variant functional connectivity analysis of intracranial electroencephalographic signals.”

Neuroimage 56.3 (2011): 1122-1133.